KRYSTEXXA ® (pegloticase) is indicated for the treatment of chronic gout in adult patients who have failed to normalize serum uric acid and whose signs and symptoms are inadequately controlled with xanthine oxidase inhibitors at the maximum medically appropriate dose …
provider for the most current information.The recipient will receive more details and instructions to access this offer.By clicking send, you acknowledge that you have permission to email the recipient with this information.The recipient will receive more details and instructions to access this offer.By clicking send, you acknowledge that you have permission to email the recipient with this information. In the present study we demonstrated that multiple doses of pegloticase administered every 2 or 4 weeks effectively controlled urate levels over 12–14 weeks in most patients with treatment‐failure gout.
Controlled studies in pregnant women show no evidence of fetal risk.Recombinant, pegylated uric acid specific enzyme; achieves its therapeutic effect by catalyzing oxidation of uric acid to allantoin, thereby lowering serum uric acid levelsPremedicate with antihistamines and corticosteroidsMonitor serum uric acid levels prior to infusions and consider discontinuing treatment if levels increase to >6 mg/dL (especially if 2 consecutive levels > 6 mg/dL observed)Administer IV infusion over at least 2 hr via gravity feed or volumetric infusion pumpStore refrigerated in original carton (do not freeze)Adding plans allows you to compare formulary status to other drugs in the same class.To view formulary information first create a list of plans.
Indicated for treatment of chronic gout in adult patients refractory to conventional treatmentHemolysis and methemoglobinemia in patients with G6PD deficiencyAnaphylaxis and infusion reactions have been reported; these reactions may occur with any infusion, including the first, and typically manifest within 2 h of infusion (although delayed-type hypersensitivity has also been reported)Only administer in a healthcare setting, and monitor for appropriate period following infusionPremedicate with antihistamines and corticosteroidsRisk for anaphylaxis is higher if serum uric acid level >6 mg/dL, monitor serum uric acid levels before infusion and consider discontinuing if levels increase to >6 mg/dL (particularly if 2 consecutive levels of >6 mg/dL are observed)Do not administer to patients with history of G6PD Deficiency; Screen patients at risk for G6PD Deficiency prior to initiating therapy; Life threatening hemolytic reactions and methemoglobinemia have been reported in these patientsG6PD-deficiency (increased risk of hemolysis and methemoglobinemia)Gout flare frequently observed (initiate gout flare prophylaxis with NSAID or colchicine at least 1 wk before starting pegloticase); gout flare prophylaxis recommended for at least first 6 monthsScreen patients at higher risk of G6PD deficiency, especially those of African and Mediterranean ancestryCaution with congestive heart failure (not formally studied in patients with CHF); congestive heart failure exacerbation may occur; monitor patients closely following infusionUnknown if retreatment after stopping for longer than 4 wk increases risk of anaphylaxis, infusion reactions, or immunogenicityRisk of infusion reaction is increased in patients whose uric acid is >6 mg/dL; if less than severe infusion reactions occur, may slow infusion or infusion stopped and restarted at lower rate at physician's discretionDiscontinue use of oral antihyperuricemic agents prior to therapy; do not initiate during course of therapy; agents may delay interpretation of ineffective pegloticase treatmentPatients may be at increased risk for anaphylaxis and infusion reactions, when treatment is discontinued for >4 weeks, due to potential to immunogenicityAdministered by IV infusion over no less than 120 min via gravity feed, syringe-type pump, or infusion pumpPre-medicate patients with antihistamines and corticosteroids before treatingMonitor serum uric acid levels before each infusionThere are no adequate and well-controlled studies in pregnant womenNot known whether drug is excreted in human milk; drug should not be used when breastfeeding unless clear benefit to mother can overcome unknown risk to newborn/infant.A: Generally acceptable. 329958-overview
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Contact the applicable plan See videos to help answer your questions.The ACR is accepting applications for mini curriculums, which are educational activities or curriculums to enhance the ACR Core Curriculum Outline.Glucose-6-phosphate dehydrogenase (G6PD) deficiency.
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