The results observed in the GARNET trial indicate the potential of dostarlimab to offer a new treatment option for women with this challenging disease.”The safety population included all patients with dMMR endometrial cancer who received at least one dose of dostarlimab (n=104). Final gross price and currency may vary according to local VAT and billing address. For further information on how we protect and process your personal information, please refer to our Please choose your email permissions
The majority of participants with endometrial cancer are diagnosed in early stages (Stage I or II) and receive surgery with curative intent; however, approximately 20% are diagnosed with advanced or metastatic disease (Stage III or IV) for which a surgical cure is not possible. Please refer to our
[6]GSK is focused on maximising patient survival through transformational medicines. Fallopian tube cancer; Ovarian cancer; Peritoneal cancer Lung cancer remains one of the leading causes of deaths from cancer worldwide, with ∼80% of all cases presenting as non-small-cell lung cancer (NSCLC).1, 2 Currently, the standard first-line treatment for patients with advanced NSCLC without targetable driver mutations is platinum-based, two drug chemotherapy regimens, which achieved a median overall survival of 10.3 … The EQ-5D-5L also includes a visual-analogue scale of overall health on a 100-point scale (from "Worst imaginable health state" to "Best imaginable health state").EORTC QLQ-C30 is validated questionnaire to assess overall health-related quality of life in participants with cancer and is composed of 30 questions including multi-item scales and single item measures. Please enter your official email address Price : $50 * Buy Profile. [3]In addition to GARNET, dostarlimab is being investigated for women with recurrent or primary advanced endometrial cancer in combination with standard of care (chemotherapy) in the phase III RUBY trial. If you are a subscriber to this content then contact us at You have the right to opt-out of sharing your email address with your organization but doing so may negatively affect your organization’s decision to renew their subscription to AdisInsight. Axel Hoos, Senior Vice President and Head Oncology R&D, GSK said: “We are committed to developing medicines for patients who face high unmet medical need. Dostarlimab (TSR-042), an investigational antiPD-1 therapy, demonstrated durable responses across subgroups of patients with microsatellite instability–high (MSI-H) and microsatellite stable (MSS) advanced or recurrent endometrial cancer, according to results from the phase I/II GARNET study. This study consists of a Screening Period, Treatment Period, an End of Treatment (EOT) Visit, a Safety Follow-up Visit, and a Survival Assessment Period. ClinicalTrials.gov. Scores are averaged, and transformed to a 0-100 scale; a higher score represents a more severe overall side effect of treatment.An AE is any untoward medical occurrence in a clinical study participant, temporally associated with the use of a study intervention, whether or not considered related to the study intervention. You have reached the maximum number of saved studies (100).Please remove one or more studies before adding more.European Network of Gynaecological Oncological Trial Groups (ENGOT)Endometrial cancer accounts for greater than 90 percent (%) of all uterine cancer. An SAE is any untoward medical occurrence that, at any dose: results in death, is life-threatening, requires inpatient hospitalization or prolongation of existing hospitalization, results in persistent or significant disability/incapacity, is a congenital anomaly/birth defect or any other situation according to medical or scientific judgment.Any event that was not present prior to the initiation of study treatment or any event already present that worsens in either intensity or frequency following exposure to study treatment will be considered as TEAE.Blood samples will be collected for the assessment of clinical hematology parameters.Blood samples will be collected for the assessment of clinical hematology parameters.Blood samples will be collected for the assessment of clinical hematology parameters.Blood samples will be collected for the assessment of clinical hematology parameters.Blood samples will be collected for the assessment of clinical hematology parameters.Blood samples will be collected for the assessment of clinical chemistry parameters.Blood samples will be collected for the assessment of clinical chemistry parameters.Blood samples will be collected for the assessment of clinical chemistry parameters.Blood samples will be collected for the assessment of clinical chemistry parameters.Blood samples will be collected for the assessment of clinical chemistry parameters.Blood samples will be collected for the assessment of clinical chemistry parameters.Urine samples will be collected at indicated time points for the assessment of specific gravity. Urine specific gravity is a measure of the concentration of solutes in the urine and provides information on the kidney's ability to concentrate urine.
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